The extracellular matrix of cartilage consists of collagen , hyaluronic acid, glycoproteins, proteoglycans and water. Chondroblasts are found in the perichondrium of the cartilage. Perichondrium is the thin layer of connective tissue that protects the cartilage. When needed, the chondroblasts are activated by hormones such as growth hormones and thyroid hormones and secrete the extracellular matrix. This causes the cartilage to enlarge. This type of cartilage growth is known as appositional growth.
The extracellular matrix secreted by chondroblasts is located in the outer covering of the cartilage. Once chondroblasts are trapped in the extracellular matrix, the cells become chondrocytes. Chondroblasts are shown in Figure 1.
Chondrocytes are the mature form of chondrocytes that are embedded in the self-secreted, extracellular matrix of the cartilage. These cells are made up of chondroblasts, which secrete the extracellular matrix.
This extracellular matrix forms lacunae in which the chondrocytes are located. Chondrocytes are the only cell type found in mature cartilage. The extracellular matrix that surrounds chondrocytes consists of sulfated glycosaminoglycans. Chondroblasts are the progenitors of the chondrocytes and extracellular matrix of the cartilage. When chondroblasts are embedded in the cartilage matrix and cease dividing, they become chondrocytes.
Chondrocytes are the specialized mature cells found in the cartilage which produces and manages the cartilage matrix. Chondrocytes are composed of collagen fibrils and proteoglycans and responsible for the flexibility of the cartilage. This is the difference between chondroblasts and chondrocytes.
Reference: 1. Wiley Subscription Services, Inc. Zhang, Minjie, Sriniwasan B. Mani, Yao He, Amber M. Jay, and Matthew L. American Society for Clinical Investigation, 01 Aug. Image Courtesy: 1. Jun 19, CC BY 3. Samanthi Udayangani holds a B. Degree in Plant Science, M. Perichondrium is the thin layer of connective tissue , which protects the cartilage.
When needed, the chondroblasts are activated by hormones such as growth hormones and thyroid hormones and secrete the extracellular matrix. This increases the size of the cartilage. This type of growth in cartilage is called the appositional growth. The extracellular matrix secreted by chondroblasts can be found in the outer covering of the cartilage. Once chondroblasts are trapped inside the extracellular matrix, the cells become chondrocytes. Chondroblasts are shown in figure 1. Chondrocytes are the mature form of the chondrocytes, which are embedded in the self-secreted, extracellular matrix of the cartilage.
These cells are formed from chondroblasts, which secrete the extracellular matrix. This extracellular matrix form lacunae in which the chondrocytes are located in. Chondrocytes are the only cell type found in a mature cartilage. The extracellular matrix, which surrounds chondrocytes, are composed of sulfated glycosaminoglycans.
Any imbalance in the vitamin or retinoid levels during pregnancy may lead to skeletal malformation. For this reason, maintenance of Vitamin A levels in pregnant women is critical to avoid any skeletal malfunctioning. Malfunctioning chondroblasts can result in tumors or cancers —for example, unregulated cell division and growth in chondroblast results in chondrosarcoma or chondroblastomas. Chondrosarcomas is the malignant tumor formation that forms due to malfunctioning chondroblasts.
On the other hand, chondroblastomas are benign tumors. These tumors are formed at the endochondral ossification sites, i. Thighbone femur , shinbone tibia , or humerus the upper arm are some of the most common sites for chondroblastoma formation. Similarly, malfunctioning hypertrophic chondrocytes can result in osteoarthritis and bone growth.
Now, let us understand what chondroblasts do. Chondroblast cells function to carry out the development, maintenance, growth, and homeostasis of the cartilage tissue.
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