The therapeutic potential of ayahuasca as a therapy tool in psychotherapy has generated significant clinical interest and several clinical trials have reported beneficial effects in the treatment of addiction and depression. The growing mainstream appreciation for the therapeutic potential of ayahuasca DMT-containing brew and other classical psychedelics has generated increased scientific interest as to whether DMT has therapeutic potential. Scientific studies have demonstrated similarities between DMT and psilocybin, whereby DMT is able to produce a comparable mystical experience to that of psilocybin.
It is suggested that psilocybin alters brain activity and enables the brain to reset. Therefore, recent evidence that DMT causes changes in human brain activity could be of therapeutic value. These similarities suggest that DMT may have a similar therapeutic potential to psilocybin in treating psychiatric disorders such as depression and anxiety. DMT induces a particularly potent psychedelic experience consisting of intense visual alterations and hallucinations, alongside alterations in emotion and mood.
The intensity of the trip can be emotionally challenging for some people, inducing states of panic, anxiety and paranoia. For some people DMT produces an out-of-body experience or depersonalisation, which can be an overwhelming experience. A sober sitter is an important safety measure to mitigate psychological harm. Similar to other psychedelics, history of mental health illness such as schizophrenia, psychosis and bipolar disorder may increase the likelihood of an unpleasant experience and there is the risk DMT may exacerbate these conditions.
However, there is still a limited understanding of the risks associated with the use of psychedelics in those with pre-existing mental health conditions. This can result in a potentially life-threatening condition called serotonin syndrome. This includes some antidepressants and selective serotonin reuptake inhibitors SSRIs.
DMT should not be mixed with alcohol or other drugs and an understanding of the effects and mechanism can provide insight into the risks associated with mixing it with other drugs. Key drug combinations to avoid are listed below:. DMT, along with other classical psychedelics, is not addictive.
However, tolerance can develop with frequent use, whereby a higher dose is required to achieve the same effect. DMT is a powerful psychedelic drug that can produce a rapid and intense hallucinogenic experience. Informed harm reduction advice can help to mitigate some of the associated risks.
It is important that you fully educate yourself on the health risks and drug interactions associated with DMT. It is important to ensure that the correct form and method of consumption is used, as well as a suitable dose. The particularly intense nature of DMT makes it important that sufficient preparation is done. This includes an awareness of the psychological and physical effects that DMT may induce.
This can have a significant effect on the experience of the trip and therefore it is advised that DMT is only consumed when a person is in a positive and stable state of mind. DMT should be consumed in a safe and calm environment, due to the intensity of the trip and the potential motor impairments.
Medically reviewed by Dena Westphalen, Pharm. Still, DMT carries some risks. What are the negative side effects? Are there any risks linked to it? What about interactions with other drugs? Is it addictive? Is it legal? Safety tips to keep in mind. The bottom line. Read this next. Medically reviewed by Alan Carter, Pharm. Medically reviewed by Zara Risoldi Cochrane, Pharm. What influences how long it lasts? How long does it take to kick in? How long does it stay in your system? Are there any comedown effects?
Will it show up on a drug test? Are there any risks involved? Harm reduction tips. The bottom line. Read this next. Medically reviewed by Alan Carter, Pharm. How Long Does Acid Last?
What to Expect. What an Introvert Is — and Isn't. Medically reviewed by Kendra Kubala, PsyD. Unregulated drugs like DMT are dangerous and illegal, and there is no guarantee that someone will have a safe or positive experience. If someone or someone you know is abusing DMT, contact a treatment provider to discuss available treatment options. She earned a B. A passion for writing led her to a career in journalism, and she worked as a news reporter for 3 years, focusing on stories in the healthcare and wellness industry.
Knowledge in healthcare led to an interest in drug and alcohol abuse, and she realized how many people are touched by addiction. All of the information on this page has been reviewed and verified by a certified addiction professional. Her Small, Women, and Minority owned SWaM firm is committed to increasing drug and alcohol awareness in the community and decreasing the prevalence and debilitating impact of substance abuse. Dayna is a seasoned counselor with experience in a variety of therapeutic milieus.
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